F09 - The Lifespan of a Research Protocol: The Journey From Research Using Animals to Research Involving Humans

Research may move from the laboratory to human subjects or from animal models to human subjects. Animal-to-human research/clinical trials is neither a one-way street nor is it a straight line/sequential; there might be many back and forths. What clinicians see in practice may end up back in the animal research realm to better understand underlying mechanisms so as to develop preventions and cures. Is the information from the animal research limited in time in its applicability? Are there reasons to revisit research in animals at different stages when it is used in humans or triggered by certain events. Is the characterization of an adverse event different for the two species? Should it be? And, how do we define the relevance of adverse events in animals to adverse events in humans?